| Sol No.: |
Navy SBIR FY2010.2 |
| Topic No.: |
N102-179 |
| Topic Title: |
Artificial Tissue Matrices for Bone Repair |
| Proposal No.: |
N102-179-0359 |
| Firm: |
MO-SCI Corporation
4040 Hypoint North
Rolla, Missouri 65401-8277 |
| Contact: |
Mariano Velez |
| Phone: |
(573) 364-2338 |
| Web Site: |
www.mo-sci.com |
| Abstract: |
This Small Business Innovation Research (SBIR) by Mo-Sci Corporation in collaboration with the Indiana University School of Dentistry (IU) and the Missouri University of Science & Technology (Missouri S&T) proposes to use bioactive glass bone scaffolds for bone repair. The objective is to develop a completely artificial bone substitute material that mimics human bone and can replace long bones, facial bones and skull bones. The new bioactive glass scaffolds are biodegradable and biocompatible and are synergistic with the natural bone tissue regeneration process. The scaffolds are manufactured by selective laser sintering (SLS), to mimic the structure and mechanical properties of normal healthy trabecular bone tissue, and with good capability for vascularization. The bioactive glass scaffolds will be tested if can function as carrier for Bone Morphogenic Protein-2 (BMP-2) and induce bone healing in small animals in Phase I. Mo-Sci Corp. will develop the SLS scaffolds as Intellectual Property, then work with the American Medical Association and the Food and Drug Administration (FDA) to gain the necessary approvals to begin making the SLS bone scaffolds available to greater medical community. |
| Benefits: |
Bioactive glass bone scaffolds are proposed as resorbable woven bone tissue to provide the mechanical support and structure necessary for the regeneration of normal bone tissue. The inflammatory process of natural bone regeneration is critical for bone repair in order to provide an abundant nutrient supply and efficient waste removal in support of the subsequent bone tissue regeneration and remodeling metabolism. Resorbable load-bearing bone scaffolds that mimic the structure and mechanical properties of woven bone can be made by using bioactive glass and selective laser sintering (SLS). This innovative scaffold fabrication technology will be applied to in vitro and in vivo bone-tissue engineering as well as a synthetic-graft material for direct implantation. These bone tissue scaffolds can be used directly as synthetic bone grafts in order to meet the needs of the increasing number of individuals who will require restoration of skeletal structure and function due to bone disease and fracture in the next decade. |