Miniature, Portable, Device to Detect and Monitor Coagulopathy Navy STTR FY2010.A Sol No.: Navy STTR FY2010.A Topic No.: N10A-T043 Topic Title: Miniature, Portable, Device to Detect and Monitor Coagulopathy Proposal No.: N10A-043-0816 Firm: NanoMason 610 The Parkway Ithaca, New York 14850 Contact: Norimasa Yoshimizu Phone: (607) 216-8263 Web Site: www.nanomason.com Abstract: Conventional coagulation tests use an isolated portion of the blood coagulation cycle to assess blood function by activating pathways of the cycle via chemical additives. Thromboelastography (TEG) is an effective tool for monitoring the entire coagulation cycle as a whole from a physical standpoint i.e. from the clot formation to fibrinolysis. Information about the quality and dynamics of clot formation can also be derived. However, current TEG devices are large and bulky which require up to 30 minutes for estimating critical coagulation parameters. Also, activating coagulation by precise rotation of its cuvette is a delicate process, and there is significant data processing to extract the reaction and clot formation times, and maximum amplitude to finally determine the coagulation index. Therefore, there is a need for a fast, low cost, portable, and rugged device to monitor blood coagulation during blood component therapy in remote sites for treating traumatic injuries. We will develop a technology to monitor fluid viscosity and shear-dependent viscosity by using longitudinal and flexural modes of microfabricated silicon probes. These devices will enable real-time monitoring of whole blood coagulation without the addition of anticoagulants. Benefits: The technology developed will expand the capabilities of coagulopathy monitoring to complete monitoring of treatment/therapy effectiveness in real time. Medical diagnosis of disease often requires the viscosity of body fluids, most importantly that of blood. Also, monitoring plasma viscosity can help in the prediction and diagnosis of plasma hyperviscosity syndrome and sickle cell disease. Additionally, a measure of blood viscosity can help in monitoring interventions to alter blood viscosity such as diet, alcohol, pharmaceuticals etc. Therefore, development of blood viscosity measuring will give a complete picture of therapy induced changes to patient blood and enable real-time feedback of treatment effectiveness. Return