A Rugged and Miniaturized Optical Coagulation Monitor
Navy STTR FY2010.A


Sol No.: Navy STTR FY2010.A
Topic No.: N10A-T043
Topic Title: A Rugged and Miniaturized Optical Coagulation Monitor
Proposal No.: N10A-043-0004
Firm: Spectral Sciences, Inc.
4 Fourth Avenue
Burlington, Massachusetts 01803-3304
Contact: Brian Gregor
Phone: (781) 273-4770
Web Site: www.spectral.com
Abstract: A team consisting of Spectral Sciences Inc., Boston University, Boston University Medical School, Radcliffe Consulting and Brighton Consulting will collaborate to develop and validate a novel optical device for the monitoring and evaluation of blood coagulation. In this proposal we describe a novel optical blood coagulation monitoring instrument. The instrument has no moving parts, uses very small blood samples, and will be compact enough to be handheld. Due to its all optical nature and temperature controlled sample stage the instrument will be usable in a wide array of environmental conditions and be suitable for use in medical facilities in military field deployments. In Phase I the concept will be validated using an existing tabletop version at Boston University and the results characterized for the development of a prototype in Phase II.
Benefits: Military and civilian medical personnel have a need for a compact and rugged coagulation monitor to aid in blood component replacement therapy. Blood loss in patients with severe trauma can be significantly worsened by coagulopathy, a condition in which blood fails to clot appropriately. Blood component replacement therapy is used to treat coagulopathy by introducing plasma and blood platelets into the bloodstream of the patient. The therapy needs to be guided by measuring the coagulation properties of blood as the treatment is administered. Coagulopathy is also a concern following a number of types of surgery. The monitor will be capable of operating in widely varying temperatures and withstand rough handling and shock in field deployments and usage. The introduction of this coagulation monitor to the marketplace will be a valuable addition to hospitals and trauma care centers, both military and civilian.

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