Multi-functional Synthetic Co-polypeptides as Hemostatic Agents Navy SBIR FY2010.1 Sol No.: Navy SBIR FY2010.1 Topic No.: N101-085 Topic Title: Multi-functional Synthetic Co-polypeptides as Hemostatic Agents Proposal No.: N101-085-1962 Firm: NanoPacific Holdings, Inc. 10960 Wilshire Blvd. Suite 950 Los Angeles, California 90024 Contact: Diego Benitez Phone: (310) 268-9494 Web Site: www.nanopacific.us Abstract: The objective of this proposal is to optimize a synthetic co-polypeptide formulation for the treatment of traumatic wounds. We employ a robust synthetic platform to access diverse functional co-polypeptides formulated as nanoemulsions, vesicles, micelles and optically clear hydrogels. Prior studies have demonstrated biocompatibility and wound healing with synthetic co-polypeptide hydrogels in murine models. Preliminary coagulation screens of polypeptide preparations (varying size and charge) showed wide differences in plasma gel formation and thromboplastin induced plasma clotting times. We propose to design and optimize hemostatic elements into our synthetic co-polypeptide preparations. Initially, we will test changes in primary structure and concentrations of co-polypeptides. Efforts focus on charge distribution (to enhance coagulation), high polypeptide content (to absorb water), hydrogel formulation (to provide matrix-like structure) and combinations thereof. Moreover, our synthetic co-polypeptides are compatible with active pharmaceutical agents, including various hemostatic materials. For commercialization of the hemostatic medical aid, we will seek partners with experience selling through both military and private sector channels. We believe that the distinct advantage of our approach -independent and orthogonal modification of structure-to-function relationships- will support the design of a more effective medical aid for the treatment of major trauma and burn injuries. Benefits: The anticipated benefits are the creation of a synthetic co-polypeptide formulation for the treatment of hemorrhagic trauma. If successful, we will explore the potential of co-polypeptides as hemostatic agents. We will determine the structure-function relationships of co-polypeptides related to hemostatics, including mechanical and procoagulant activities. We anticipate that our materials can be made into a gel that can be applied from a pressurized container on many different types of traumatic wounds. Return